Is your problem that they are greyed out or that they are not greyed out and clicking them doesn't work?
You need to have the amount of hand ins collected before you can hand in as indicated next to the chat options e.g. (6) - if not the chat option will be greyed out.

If you don't speak with the boy before running after the cat it seems to bug.

I had issue when:

• Speaking to the cat.
• Boy comes running but did not speak to him.
• Followed cat to where it stopped.
• Cannot interact with cat.
• Ran back to boy and spoke with him.
• Boy runs after cat.
• When arriving at cat location unable to interact with cat
• Cat runs back past the boy.
• Cat and boy are now stuck unable to interact with any of them.

I had no issue when:

• Speaking to the cat.
• Boy comes running and spoke with boy.
• Run with boy to find the cat.
• Could interact with the cat at it's location and event completed.

Workaround:
Continue on your way with quests/fast travel/wait and it will eventually reset cat and boy back to original starting place.

@driton_the_don

Just adding it here for good measure, but in some places you can see the marker etc in a place where there will be a future wealth chest.
What I mean is for some places there is nothing but the marker (more or less) but later you get a quest to go there and there is now a bandit camp or something in which the wealth chest is spawned.

If you are sure you are in the right place you might want to just go on about your day and hopefully get it later

@sunnfyre

I had something similar, I first completed the Arc of Lunden then went to find her and she was nowhere to be found.
Eventually she spawned back where she had to be, but it took a long time, so keep checking every now and then and I hope you find her!

@premi_pulkit

Thank you for this. I had no problems for the first days, then suddenly I started the game up this morning and I had black bars...
I don't have a 144hz monitor yet so that work around was out of scope for me, but thankfully BorderLess gaming fixed it.

It's a bit sad to rely on a third party program for an issue that occurs magically overnight, but what can you do..

@premi_pulkit

It still said native in AC, but I reckon you are still right. I will add that my screen was a bit old and it has been known to doing some wonky things. I got a new screen yesterday and I indeed no longer have the problem!

@driton_the_don

Just adding it here for good measure, but in some places you can see the marker etc in a place where there will be a future wealth chest.
What I mean is for some places there is nothing but the marker (more or less) but later you get a quest to go there and there is now a bandit camp or something in which the wealth chest is spawned.

If you are sure you are in the right place you might want to just go on about your day and hopefully get it later

@dexadrinne

It's not E to let go, it's a different button you can see it in your key mapping. I've changed it so I don't know anymore what the default is.
This also had me confused in the start!

@premi_pulkit

Thank you for this. I had no problems for the first days, then suddenly I started the game up this morning and I had black bars...
I don't have a 144hz monitor yet so that work around was out of scope for me, but thankfully BorderLess gaming fixed it.

It's a bit sad to rely on a third party program for an issue that occurs magically overnight, but what can you do..

@sunnfyre

I had something similar, I first completed the Arc of Lunden then went to find her and she was nowhere to be found.
Eventually she spawned back where she had to be, but it took a long time, so keep checking every now and then and I hope you find her!

@killermarcei

Indeed, this is my impression as well. It also seems like this one can't be fixed with the standard "wait until it resets" like others, even if it does reset, the moveable wall things does not spawn in their original state, and in my game they are spawned even on top of new jars..

Have opened the way fully as can be seen on the screenshot below but the man won't walk out. Comparing mine with some videos on youtube it looks like my boxes are slightly in the wrong position for some reason.
https://imgur.com/yVtUuZC

When I quick load with F9, instead of loading the latest saved game, it loads one of the first saves back in Norway in the prologue.

I think I have found the worst offender.
It might be somehow linked to adrenaline

I recorded a clip of it, as you can see it's a bit too much.

If you don't speak with the boy before running after the cat it seems to bug.

I had issue when:

• Speaking to the cat.
• Boy comes running but did not speak to him.
• Followed cat to where it stopped.
• Cannot interact with cat.
• Ran back to boy and spoke with him.
• Boy runs after cat.
• When arriving at cat location unable to interact with cat
• Cat runs back past the boy.
• Cat and boy are now stuck unable to interact with any of them.

I had no issue when:

• Speaking to the cat.
• Boy comes running and spoke with boy.
• Run with boy to find the cat.
• Could interact with the cat at it's location and event completed.

Workaround:
Continue on your way with quests/fast travel/wait and it will eventually reset cat and boy back to original starting place.