Just bought the Division 2.
At the start i noticed some noise flickering on the screen. Switched to DX12.It seems to be fixed.
After this , the game started to crashed (tried on dx11 and dx12).
I followed the 2 steps recommended

1. Compatibility with windows 8.
2. What magmum said, disabled the ingame overlay.

So far after 50 minutes no more crashes. This afternoon i will play some hours, and comeback to edit the reply.

Edit 1: I didnt realized i didnt applied the windows 8 compatibility. I was only playing with the ingame overlay disabled.
Now this time with the windows 8 compatibility applied, still no crash in another hour of game play.
Amd Rx 660 and Fullscreen Borderless.

Edit 2. I got 1 crash today.

After reporting with no success and trying almost everything, i decided to keep playing no matterwhat.
Yes, the game crashes from time to times, even with the overlay from ubisoft launcher deactivated ( this helped a lot), i am on amd 6600 card, and i noticed something, the game crash when it tries to do save game or save state, whatever you want to call it, fill ammo from box (crash sometimes) , grab an item which a leader drop (crash sometimes), after finish any objectives and i assume wants to update and save (crash some times). And i want to add, every time i open the game, the first crash is quick, after i close and open again quickly, it doesnt crash for a long periods of time.

Would you please fix this already ?.

@marcoavll

I will continue here my updates.

Update 4. Yesterday (sunday), i couldnt start the game, it showed an error when the anti cheat was loading Error 22 if i'm not mistaken, looking around here and there i did a Check Integrity files (nothing wrong and the end), and acorrding to a forum, i changed the Anti Cheat (in the services.msc) to Automatic (it was Manual), and after i restarted again the game, did the whole process of installing directx and everything. It seems to be fixed because i could start the game again.

Update 5.. Back to my main issue, i had one more crash last night, and i thought if the game was gonna keep crashing randomly, well i activated the ingame overlay again, and when i started to play just after 5 minutes, crashed. So, i ended up deactivating the ingame overlay, after that i could play one hour, and this morning another hour.

Conclussion: I think i'm not gonna improve anything more so at the end i got this:

1. Ingame overlay deactivated.
2. Windows Fullscreen Borderless (i read that could help because it can crash for using ALT + TAB constantly, and yes, i use ALT+TAB every 5 minutes).
3. Anticheat in Automatic in Services.msc.
4. Graphic setting on High.
5. I updated my Amd drivers to the very last one (22.2.1, i had the previous one).

All this seems to help, at least improve a lot, but is not a solid fix. And i've read around the division 2 has a hardcore mode, and i never tried hardcore on any game before because i dont have that much patience, but this game i really like it, so i would like to try hardcore, BUT, if these guys from ubi dont fix this once for all (which it seems they are not gonna do it), that experience will be ruined for a crash. It's up to you Ubisoft.

@mr-t-magnum Thanks for the idea :-). Will try this if i get another crash. Just got home so, i will play later a couple of hours. Cheers.

Edit. Yep,. i meant the XFX 6600 (not the xt). I just looked and i missed a zero there xD.
Update. Just crash once just now. Gonna try your advice.
Update 2. Just looked for that option on windows 10. I dont have it.
  Update 3. One more crash even running as a administrator, windows mode fullscreen and overlay deactivated.

Trying another workaround from this very same forum.
Right now in 2022, and after some years (since this happened to me also in the first division game, you have to solve this Ubisoft, stop gaining time with tickets and reports. The problem is still there, and by now you must have all the info needed.

Just bought the Division 2.
At the start i noticed some noise flickering on the screen. Switched to DX12.It seems to be fixed.
After this , the game started to crashed (tried on dx11 and dx12).
I followed the 2 steps recommended

1. Compatibility with windows 8.
2. What magmum said, disabled the ingame overlay.

So far after 50 minutes no more crashes. This afternoon i will play some hours, and comeback to edit the reply.

Edit 1: I didnt realized i didnt applied the windows 8 compatibility. I was only playing with the ingame overlay disabled.
Now this time with the windows 8 compatibility applied, still no crash in another hour of game play.
Amd Rx 660 and Fullscreen Borderless.

Edit 2. I got 1 crash today.